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Properties of gold films sputtered under different conditions onto borosilicate glass substrate were studied. Targeting sarcoplasmic reticulum calcium ATPase by gene therapy. To meet current challenges in agriculture, genome editing using sequence-specific nucleases (SSNs) is a powerful tool for basic and applied plant biology research. Moxifloxacin, a fluoroquinolone antibiotic associated with QT prolongation, has been recommended as a positive control by regulatory authorities to evaluate the sensitivity of both clinical and preclinical studies to detect small but significant increases in QT interval measurements.

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A total of 3200 participants aged 15-50 years were enumerated and examined using the Rapid Assessment of Refractive Error (RARE) protocol. Strains of S.pneumoniae contain PBP-1A, PBP-2B and PBP-2X proteins. We identified several metabolic pathways underlying altered protein expression. A computerised method of analysing fetal heart rate and uterine activity using a simple algorithm has demonstrated a capability to predict fetal acidosis at the time of delivery. Vulnerable children should be a key focus of healthcare interventions if inequities are to be addressed.

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High-resolution three-dimensional diffusion-weighted imaging of middle ear cholesteatoma at 3.0 T MRI: usefulness of 3D turbo field-echo with diffusion-sensitized driven-equilibrium preparation (TFE-DSDE) compared to single-shot echo-planar imaging. Pain with activity was the strongest predictor of participant satisfaction.

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Overall, clinical benefit was not obtained by mRH in patients with clinical stage I/II endometrial carcinomas. Short tandem repeat (STR) analysis of casework samples with low DNA content include those resulting from the transfer of epithelial cells from the skin to an object (e.g., cells on a water bottle, or brim of a cap), blood spatter stains, and small bone and tissue fragments.

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A quasi-experimental, pre- and post-test questionnaire study of men at 14 workplace and leisure sites across two primary care trusts was undertaken: ten experimental sites received the intervention and four acted as a control. Previous studies have shown that treatment of these cells with tetanus toxoid or anti-human IgG reagents can inhibit this in vitro antibody synthesis. C57BL/6 mice infected with the helminth Schistosoma mansoni develop small hepatic granulomas around parasite eggs, but concomitant immunization with soluble schistosome egg Ags (SEA) in CFA (SEA/CFA) causes marked exacerbation of the lesions in a Th1-dominated environment characterized by high levels of IFN-gamma.

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Beta-lactamase inhibition with clavulanic acid supplementing standard amoxycillin-based triple therapy does not increase Helicobacter pylori eradication rate. They also act as a fence against mixing of membrane proteins of the apical and basolateral side. The patient died due to septic shock after 16 hours from the referral. To assess the influence of genetic polymorphisms of IL4RA, IL13, TNFA, IL1A, and IL5 on the decline of lung function and bronchial hyperresponsiveness in a prospective follow-up study of baker/pastry maker and hairdresser apprentices. Corneal abrasion resulting from a unit dose artificial tear dispenser.

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Our objective is to identify steps in designing an effective simulation program, curricula, and scenario using available evidence and drawing on experience. Recognition of tumor-suppressive miRNA-regulated molecular targets provides new insights into the potential mechanisms of cervical SCC oncogenesis and metastasis and suggests novel therapeutic strategies for treatment of this disease.

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The effect of pronation and inclination on the measurement of the hallucal distal metatarsal articular set angle. Clinical evaluation of pravastatin in the treatment of type II hyperlipidemia in patients with non-insulin-dependent diabetes mellitus. None of the currently available agents has been proven to prevent regurgitation.

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This association is probably not fortuitous but, rather, may represent the most extreme form of a spectrum of left-sided heart anomalies seen in patients with Turner syndrome. By using a mammalian genetic replacement strategy, we were able to assemble fluorescently tagged Sec8 into the exocyst complex, which was shown to be functional by biochemical, trafficking, and morphological criteria. Fetal venous, intracardiac, and arterial blood flow measurements in intrauterine growth retardation: relationship with fetal blood gases. Although hyperglycemia is a key therapeutic focus in the management of patients with type 2 diabetes mellitus (T2DM), many patients experience sub-optimal glycemic control.

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We utilised a mu suppression method in our action-listening study to detect involuntary motor coactivation when pianists passively listened to piano melodies. In this study, we examined ICAM-1 expression by primary rat microglia and found that only IFN-gamma and IFN-gamma/LPS enhance ICAM-1 gene expression. Activation of lymphocytes by a thiol-derivatized nucleoside: characterization of cellular parameters and responsive subpopulations. The findings suggest that m-calpain may act at an early phase of CIA as a matrix proteinase and take part in the destruction of articular cartilage or activate other destructive enzymes. Production of medium chain length fatty alcohols from glucose in Escherichia coli.

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We report a case of spurious hyperchloraemia, elevated total carbon dioxide and negative anion gap 9 days following a voiding cystourethrogram (VCU) in a patient with bladder exstrophy and obstructive uropathy. Moxalactam, cefoxitin, and piperacillin demonstrated the best pharmacokinetic performances for the third-generation cephalosporin, second-generation cephalosporin, and newer penicillin groups, respectively. DNA double-strand breaks and micronuclei in human blood lymphocytes after repeated whole body exposures to 7T Magnetic Resonance Imaging. In diabetic patients the carbachol induced SAR response and the histamine induced itching sensation were significantly reduced in stage III of PNP.

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The elevation in the hepatoma RNA polymerase I activity resulted from both an increase in the number of transcriptionally active enzyme molecules and an increase in the specific activity of the enzyme as a result of phosphorylation. Effect of secretin and caerulein on the absorption of water, electrolytes and glucose from the jejunum of dogs. This procedure facilitates the conversion of a useless, mutilated hand into a well-functioning one in a single operation. Inappropriate exposure of gametes and/or products of conception to nutritional imbalance alters critical metabolic set points in the offspring and increases propensity to disease. Clinical significance of diabetes mellitus on detrusor functionality on stress urinary incontinent women without bladder outlet obstruction.

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In cathepsin S-deficient mouse pancreatic cancers, processing of these cathepsin substrates is highly reduced, pointing to an essential role of cathepsins in extracellular shedding. Overall, our data support a role of p120 phosphorylation as a marker and mediator of tumor transformation. Decreased expression of fibulin-5 correlates with reduced elastin in thoracic aortic dissection.

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Recently, we demonstrated that regulation of the Gtl2-Dio3 noncoding RNA locus is dependent on the MEF2 transcription factor in cardiac muscle, and that two of its encoded miRNAs, miR-410 and miR-495, induce robust cardiomyocyte proliferation. Alkaliphilic Bacteria with Impact on Industrial Applications, Concepts of Early Life Forms, and Bioenergetics of ATP Synthesis. Between January 1990 and December 2001, 670 patients underwent 920 minor amputations (interphalangeal, ray, or transmetatarsal) on 747 limbs. Pasteurized whole milk is an attractive oral contrast agent, providing good GI distension, mural visualization, and GI landmark discrimination. Organometallic coordination polymers generated from bent Bis(acetylenylphenyl)oxadiazole ligands and Ag(I) salts.

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Structural insights into the role of the cyclic backbone in a squash trypsin inhibitor. CD2 or CD28 stimulation, but not CD3/TCR stimulation, induces Dok phosphorylation. A broad spectrum of microbes including mycoplasma, bacteria, fungi, and viruses are the causative agents of cell culture contamination. These results suggest that at high cell density, the switching of binding of transcription factors from ETS1 to ELK3 occurs at a specific binding site of the PAI-1 promoter, leading to the cell-density dependent suppression of PAI-1 expression.

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The blood serum content of cholesterol, phospholipids, proteins and lipoproteins of patients with diabetes mellitus during treatment with sulfanyl-urea derivatives Dental utilization of active duty/previous active duty US military: a cross-sectional analysis of the 2010 Behavior and Risk Surveillance Survey. The HiMAT, which assesses higher-level mobility requirements of people with TBI for return to pre-accident social, leisure and sporting activities, is a uni-dimensional and discriminative scale for quantifying therapy outcomes. Youth who report risky substance use and who have a familial history of substance use disorders (SUDs) are at increased risk for developing SUDs themselves later in life. Lifelong susceptibility to acoustic trauma: changing patterns of cochlear damage over the life span of the mouse.

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Speciation, adsorption and determination of chromium(III) and chromium(VI) on a mesoporous surface imprinted polymer adsorbent by combining inductively coupled plasma atomic emission spectrometry and UV spectrophotometry. The peptide hormones prokineticins exert their angiogenic function via prokineticin receptor-1 (PKR1). DNA synthesis and nuclear reproduction during embryonic development and regeneration of muscle tissue. Visually deprived occipital cortical regions are histologically and morphologically altered and exhibit a strikingly remodeled functional state: absolute levels of neural activity are heightened and are modulated by nonvisual sensory stimulation as well as higher cognitive processes.

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HIV infection and testing among Latino men who have sex with men in the United States: the role of location of birth and other social determinants. Triage of patients for an extended observation period can be performed adequately on the basis of clinical and procedural criteria. Experimental studies: thrombolytic activity and related phenomena. nucleatum, Bacteroides gingivalis, Actinomyces viscosus, and Streptococcus sanguis.

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