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Saphire (Atorvastatin)
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Atorvastatin

Efficacy and tolerability of two different formulations of Saphire in Korean patients with hypercholesterolemia: a multicenter, prospective, randomized clinical trial. Initially, we tested the efficacy of Saphire pretreatment (1 mg/kg, daily for 10 days before ischemia) and hypothermia (32-33 degrees C for 2 h at onset of ischemia) in combination, and then we examined the effects of Saphire pretreatment on the therapeutic time window of hypothermia (3 or 6 h after ischemia).

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Saphire is used together with a proper diet to lower cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (e.g., chest pain, heart attack, or stroke) that are caused by fats clogging the blood vessels. It may also be used to prevent certain types of heart and blood vessel problems in patients with risk factors for heart problems.

Saphire belongs to the group of medicines called HMG-CoA reductase inhibitors, or statins. It works by blocking an enzyme that is needed by the body to make cholesterol, and this reduces the amount of cholesterol in the blood.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

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So far, no biologically relevant cross-reactivity at the antibody level has been demonstrated between proteins without easily-demonstrable homology. leprosum ethanolic extract (C.l.EE) in a murine model of PD using the toxin 1-methyl-4 phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). Effect of formic acid exposure on keratin fiber derived from poultry feather biomass. There was no shift in the pH optimum of the immobilized enzyme compared to that of the soluble one. Calcium, zinc, and magnesium ions were predicted to interact with the protein product of the gene.

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Use of intensity quotients and differences in absolute structure refinement. The principal toxicities from ATRA were headaches (12 patients) and dry skin or lip (seven patients).

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Case reports: successful treatment of Mycobacterium marinum infection with minocycline after complication of disease by delayed diagnosis and systemic steroids. Hepatitis C infection associates with lipid and lipoprotein metabolism disorders such as hepatic steatosis, hypobetalipoproteinemia, and hypocholesterolemia.

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In the study of blastogenic response, increased DNA synthesis of B cells by SpA Cowan I stimulation was observed in 2 patients and decreased DNA synthesis in 3 patients. In addition almitrine stimulated R beta cells classified as expiratory-inspiratory units.

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Changes in the fatty acid pattern of phosphatides in rat muscles Beetle-specific Bacillus thuringiensis Cry3Aa toxin reduces larval growth and curbs reproduction in Spodoptera littoralis (Boisd.). Changes to drug education and prevention programs may be needed to enhance understanding of drug properties and actions. Screening, monitoring, and treatment of stage 1 to 3 chronic kidney disease: A clinical practice guideline from the American College of Physicians. However, in order to provide a clear definition of the coaching interventions selected for this review, we have found it necessary to distinguish between health coaching and life coaching.

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Strong lake currents might mix pelagic waters, resulting in similar concentrations of steroids in the pelagic zone. The following 5 variables were quantified: the degree of GP, the length of the medial and lateral walls, the interzygomatic distance, and the interorbital angle.

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Haematological and iron content values for liver, spleen, intestines, blood, ovary and eggs were determined in female quails, from the prelaying state to full laying. Due to the large size and diversity of this family, PARPs affect almost every aspect of cellular life and have fundamental roles in DNA repair, transcription, heat shock and cytoplasmic stress responses, cell division, protein degradation, and much more. Impaired ABCA1-mediated cholesterol efflux in macrophages may be associated with the severity of the coronary lesions in AMI patients with the TT genotype at the -565C/T gene polymorphism. 20 years of experience in the treatment of bronchial carcinoma from the surgical point of view.

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A geochemical record of the mining history of the Erme Estuary, south Devon, UK. Birds in Anthropogenic Landscapes: The Responses of Ecological Groups to Forest Loss in the Brazilian Atlantic Forest. About 1-2 weeks after ligation, no change of ciliated cells was observed in the mucosal fold in SEM findings, nor was there much change in the external shape of non-ciliated cells even though hydrosalpinx was induced.

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Applying process mapping and analysis as a quality improvement strategy to increase the adoption of fruit, vegetable, and water breaks in Australian primary schools. The ferrous metal content of the mixture greatly impacted lead leaching. Therefore, we sought to evaluate the long-term patient outcomes following transurethral endoscopic excision using the holmium laser (TEEH).

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Activation of the interleukin-6/Janus kinase/STAT3 pathway in pleomorphic adenoma of the parotid gland. Endoscopic vein harvest does not negatively affect patency of great saphenous vein lower extremity bypass.

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Using constant and variable workload protocols on a cycle ergometer, it was investigated whether a spontaneous second wind occurs during exercise in patients with PGAMD, and using a constant workload protocol followed by an incremental load to exhaustion, it was tested whether infusion of lactate, glucose, or intralipid alters the exercise tolerance in PGAMD. Immunostimulatory CpG oligonucleotides abrogate allergic susceptibility in a murine model of maternal asthma transmission.

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Evaluation of acute kidney injury and its response to terlipressin in patients with acute-on-chronic liver failure. Facial nerve paralysis has many causes and can be acute or chronic. SeqMan II, MEGA 5.05, and eBURST V3 were applied to analyze the genetic relationships of domestic and forein existing 392 strains (243 EPEC strains included in the E.coli MLST database and 149 EPEC strains comprised in the present study).

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In a retrospective and monocentric study, the records of all the patients receiving a kidney transplant between January 2008 and December 2014 were reviewed. Although this approach is a helper virus-driven system that is technically limited and gives low levels of recombinant viruses, it allows alteration of the rotavirus genome, thus contributing to our understanding of these medically important viruses. The malformations may be of different degrees but two stages are usually distinguished. Mitochondrial energy-dissipation pathway and cellular redox disruption compromises Arabidopsis resistance to turnip crinkle virus infection. A 54-year-old female with Anderson-Fabry disease (AFD)-R342Q missense mutation on exon 7 in alpha-galactosidase A (GLA) gene - presented with sustained ventricular tachycardia.

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We characterized the metabolic phenotype of young and old raptor muscle knock-out (RAmKO) and TSC1 muscle knock-out (TSCmKO) mice, where mTORC1 activity in skeletal muscle is inhibited or constitutively activated, respectively. The results showed an association between NA and conflict with co-workers, as well as between NA and conflict with supervisors. Quantification of UV-induced erythema with a portable computer controlled chromameter. The major facilitator superfamily represents the largest group of secondary active membrane transporters in prokaryotic and eukaryotic cells.

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Two attending surgeons reviewed and graded each video of operating room performance. This unit provides detailed insights and technical knowledge in setting up one of the most widely used models of DN, the streptozotocin (STZ)-induced model. Pyrogenic stimulation of vascular resistance in conscious sheep. Refractory cytopenias: clinical course according to bone marrow cytology and cellularity. TwoStep cluster analysis was conducted to segment 2,114 high school adolescents (14-16 years old) on the basis of 22 demographic, behavioral, and psychographic variables.

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While specific immunologic defects differ, a shared hallmark is atopic dermatitis (AD)-like eczema. The study was designed to assess the effects of noninvasive electroacupuncture at Hegu (LI4) on labor pain and on adrenocorticotropic hormone (ACTH) and cortisol levels. We believe that left renal vein varicosities, influenced by mechanical and hormonal factors, produced the hematuria. Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation.

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Virulence gene expression in strains HN280 and HN280/32, as well as in derivatives harboring a mxiC::lacZ operon fusion either on the autonomously replicating pINV or on the integrated pINV, was studied. The as-prepared Pd-TMV complexes are then integrated into the poly(ethylene glycol) (PEG)-based microparticles via replica molding (RM) technique in a simple, robust and highly reproducible manner. These three examples demonstrate that HESX1 mutations cause variable clinical features in patients, which suggests an influence of modifier genes or environmental factors on the phenotype. A case of rupture of a sinus of Valsalva aneurysm in a middle-aged woman with an unusual assortment of associated conotruncal and other cardiac anomalies is reported. To explore the possibility that tumors may alter the host response via release of immunomodulatory cytokines, we studied two different skin cancers, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) as models.

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The aim of this study is to evaluate the efficacy of our current management strategy for neonates with severe pulmonary hemorrhage. We found significant amounts of 35S-AT III among the radioactive proteins synthesized and secreted by the cells. The observed sex differences are consistent with previous research regarding mechanisms underlying the sex disparity in anterior cruciate ligament injury rates. The patient was treated with quadruple anti-TB therapy for 12 months. Pt/WO3/FTO memristive devices with recoverable pseudo-electroforming for time-delay switches in neuromorphic computing.

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Primary microcephaly is a congenital neurodevelopmental disorder of reduced head circumference and brain volume, with fewer neurons in the cortex of the developing brain due to premature transition between symmetrical and asymmetrical cellular division of the neuronal stem cell layer during neurogenesis. The objective of this study was to develop a short-term experimental infection model for Mycobacterium avium subsp. Circulatory collapse and respiratory arrest occurred in a young woman shortly after taking 200 mg of zomepirac for relief of headache.

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Medical manpower in South Africa--emigration during 1975 - 1981 of doctors qualifying after 1955. Erectile Dysfunction Among Men Attending Surgical Outpatients Department in a Tertiary Hospital in South-Western Nigeria.

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The metabolism of methyl, ethyl, butyl and allyl isothiocyanate, which occur as glucosinolates in a number of plants, was studied. A dose-response study on the efficacy of tricyclic antidepressants on reducing morphine-withdrawal symptoms. Histopathologic evaluation demonstrated atypical melanocytic cells architecturally and intimately intermixed with single units and clusters of atypical squamous cells. There was no marked difference in the Se levels of patients with different types of cancer.

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Isoelectric chromatofocusing (ICF), a mode of chromatography by which proteins are separated based on changes in their charge state with pH, is widely used at analytical scales and finding increasing interest in biologics manufacturing due to its exceptional resolving power. halstedii isolate from sunflower was generated and used to design 15 polymorphic simple sequence repeat (SSR) markers. Kinetic and mechanistic characterization of the glyceraldehyde 3-phosphate dehydrogenase from Mycobacterium tuberculosis. The therapeutic benefit of physical activity to prevent and treat type 2 diabetes is commonly accepted. Examination of capsular bag-implanted intraocular lenses using an indirect contact lens during vitreous surgery.

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Traits related to the early stages of growth (in vitro germination, in vitro tube length, early in vivo pollen growth rate) were all positively correlated with each other, and these early characteristics were negatively correlated with late in vivo tube growth rate, which is largely influenced by the stylar genotype. Candida glabrata Chorioamnionitis following in vitro Fertilization: Review of the Literature. Diurnal variations in the plasma concentration of parathyroid hormone in dogs. The purpose of this study was to evaluate and compare the effectiveness of three disinfection and sterilization methods (autoclave, glutaraldehyde solution, and Deconex spray) on orthodontic markers. The effects of alcohol on the integrity of intravascular devices remain unknown.

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Due to small spin-orbit interaction the MAE of ferromagnetic films or single molecule magnets based on 3d metals is small and in typical magnetic nanostructures it is of the order of 2-3 meV. The method for ABI procedure (i.e., measurement, calculation and interpretation) is standardised and guidelines were published in 2012. While diffusion of instructional technologies has been reached a saturation point with early adopters of technology, it has remained limited among mainstream faculty. We systematically assessed both SDB and PLMs in well-defined NC patients.

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Antepartum, intrapartum, and postpartum management of therapy is discussed, as well as breastfeeding options. All patients achieved union in both groups, with the exception of a single case of nonunion in IMN group and one case of refracture after implant removal in ORIF group. Our study may support several lines of experimental evidence for a specific functional role for PRL in the growth of some pituitary adenomas. The tool consists of a comprehensive set of questions, structured along four distinct yet interrelated dimensions of sustainability factors, which all influence the success of any urban AD project. The data show that following GBP, early T-Ghr stability masks elevation of A/T-Ghr, that is stabilized after later increments of both T- and A-hormones.

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Multivariate linear regression analysis was performed to calculate the influence of age, gender, enhancement of pulmonary trunk and enhancement difference between pulmonary trunk and left atrium (as a measure of timing) on PBV values. Trends in stroke incidence in Auckland, New Zealand, during 1981 to 2003. Prolonged duration ECMO for ARDS: futility, native lung recovery, or transplantation?

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Hence, in rotated embryos, the cells containing germ plasm were invaginated earlier during gastrulation and therefore were carried further anteriorly in the endoderm to a mean position anterior to the midpoint of the endoderm. Our calculations show that anionic ligands and neutral ligands favor different electronic states for stationary points in the reaction coordinate, and the calculated energy barrier and energy of several reaction intermediates show similar values. Navigation adds costs and modestly increases the probability of diagnostic resolution among patients with abnormal screening test results.

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General transcription factor SIII, a heterotrimer composed of 110-kDa (p110), 18-kDa (p18), and 15-kDa (p15) subunits, increases the catalytic rate of transcribing RNA polymerase II by suppressing transient pausing by polymerase at multiple sites on DNA templates. On the prophylaxis and the prevention of relapse in rheumatic fever

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Patients to be interviewed were adults with at least one documented allergy in their chart. We provide a Bell test that uses arbitrarily imperfect random bits to produce bits that are, under the non-signalling principle assumption, perfectly random. Role of peripheral blood mononuclear cell transportation from mother to baby in HBV intrauterine infection.

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Biochemical and molecular characterization of a serine keratinase from Brevibacillus brevis US575 with promising keratin-biodegradation and hide-dehairing activities. In this study, we characterize the drilling kinetics of nanopores using a thermionic electron source and various electron beam fluxes to minimize secondary hole formation. Drug treatment of obsessive-compulsive disorders--a comparative study of the effectiveness of clomipramine and fluoxetine The alpha subfamily is estimated to have diverged from the beta and gamma subfamilies 200-220 million years ago.

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Privatization and its discontents--the evolving Chinese health care system. Use of del Nido cardioplegia solution and a low-prime recirculating cardioplegia circuit in pediatrics. Antibody response to bacteriophage phi-X-174 in non-mammalian vertebrates. Little attention has been directed to cognitive functions that remain intact in the disorder, though the investigation and identification of such strengths might be useful for developing new, and improving current, therapeutical interventions. Relationship of serum isoflavone, insulin and adiponectin levels with breast cancer risk.

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This review aims to briefly summarize current preclinical and neuroimaging studies that are providing a potential link between the neurotoxic effects of chemotherapy and hippocampal dysfunction, highlighting challenges and future directions in this field of investigation. Ejection fraction was unchanged during treatment, but seven of 15 patients experienced orthostatic hypotension of such severity that administration of the drug had to be discontinued. A monolayer of a clone of endothelial cells derived from rat lung cells (RLE) was overlaid with 1 M urea to extract the surface proteins.

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For children, only balance studies have been reported, but it is possible to make an estimate of their true uptake by making some allowance for endogenous fecal lead. Zucker lean rats with VA sufficient (VAS) or VA deficient (VAD) status were respectively grouped as: ad libitum (VAS-AD or VAD-AD), 48-h fasted (VAS-Fasted or VAD-Fasted), 48-h fasted and refed a VAS diet (VAS-Refed-VAS or VAD-Refed-VAS), or refed a VAD diet (VAS-Refed-VAD fluconazole 200 mg yeast or VAD-Refed-VAD) for 6 h. Cloning and functional analysis of farnesyl pyrophosphate synthase (FPPS) gene from Mylabris cichorii.

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Effect of Orexin A antagonist (SB-334867) infusion into the nucleus accumbens on consummatory behavior and alcohol preference in Wistar rats. The relationship has been found between the characteristics of the radical at the quaternary nitrogen atom and the antiarrhythmic activity of the QDT. Excess Mortality Attributable to Clostridium difficile and Risk Factors for Infection in an Historic Cohort of Hospitalised Patients Followed Up in the United Kingdom Death food and drug interactions with zoloft and advil Register. The aim was to develop a better experimental model which could facilitate further studies assessing the vertical HCV gene transmission via human spermatozoa, and verify the possibility of father-to-child transmission of the HCV gene.

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Effects of fatigue lansoprazole dose baby has right on frontal plane knee motion, muscle activity, and ground reaction forces in men and women during landing. It is presumed that the short phase of trypanosome multiplication is due to the temporary collateral oedema of the brain tissue. Accurate identification of this rare pathogen is necessary to provide appropriate treatment in granulomatous mastitis.

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Clinical inhibitron 40 mg inyectables manifestations of cutaneous nontuberculous mycobacterial infections are discussed as well as their potential association with pedicures. Quantification of Epstein-Barr virus DNA load in nasopharyngeal brushing samples in the diagnosis of nasopharyngeal carcinoma in southern China. Statistical analysis of inactivation of Listeria monocytogenes subjected to high hydrostatic pressure and heat in milk buffer.

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Clinical and genetic features of diuretic-associated precio clidets gel gout: a case-control study. The patient received four CDDP infusions of 25 mg/m2 in two courses and underwent hemodialysis before each treatment and in intervals of 48 h thereafter with blood sampling at the beginning and the end of each hemodialysis.

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